8chan/8kun QResearch Posts (5)
#19190760 at 2023-07-16 18:28:12 (UTC+1)
Q Research General #23569: Very Fascinating Life Edition
>>19190139
Agam (band)
Agam(transl.?Inner soul)is a Bangalore-based contemporary Carnatic progressive rock band. The band was formed in the year 2003. The current lineup consists of Harish Sivaramakrishnan (vocals) Swamy Seetharaman (keyboards and lyricist), T Praveen Kumar (lead guitar), Aditya Kasyap (bass guitar and backing vocals), SivaKumar Nagarajan (ethnic percussions), Jagadish Natarajan (rhythm guitar) and Yadhunandan (Drummer). Jagadish Natarajan replaced Suraj Satheesh as the rhythm guitarist in 2012 but the lineup of the band has otherwise remained same. Vignesh Lakshminarayanan was replaced by Aditya Kasyap on bass and backing vocals. Agam is often featured on the Malayalam music channel Kappa TV.
https://en.wikipedia.org/wiki/Agam_(band)
#15578904 at 2022-02-08 19:53:25 (UTC+1)
Q Research General #19700: Zuck Threatens to Cut Off Europe After HUGE Losses [10 Days?] Edition
>>15578893
>No, "HIV insertions" were not identified in the 2019 coronavirus,
FALSE.
Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
Prashant Pradhan, Ashutosh Kumar Pandey, Akhilesh Mishra, Parul Gupta, Praveen Kumar Tripathi, Manoj Balakrishnan Menon, James Gomes, Perumal Vivekanandan, Bishwajit Kundu
doi: https://doi.org/10.1101/2020.01.30.927871
https://www.biorxiv.org/content/10.1101/2020.01.30.927871v2
#13948361 at 2021-06-21 03:24:11 (UTC+1)
Q Research General #17655: Loud And Clear Edition
paper withdrawn and now back in news
https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1
Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
Prashant Pradhan, Ashutosh Kumar Pandey, Akhilesh Mishra, Parul Gupta, Praveen Kumar Tripathi, Manoj Balakrishnan Menon, James Gomes, Perumal Vivekanandan, Bishwajit Kundu
doi: https://doi.org/10.1101/2020.01.30.927871
Covid-19 lab leak theory: ==Indian scientists had flagged 'unnatural insertions' in its genome, were forced to withdraw study
Researchers from Kusuma School of Biological Sciences in IIT Delhi had published a paper last year showing that the 4 unique insertions in Novel Coronavirus match with HIV virus==
4 June, 2021
https://www.opindia.com/2021/06/indian-scientists-had-found-unique-insertions-in-covid-19-virus-genome/
"One of such studies that was brought to the notice of Fauci was a research paper by some scientists from India. In January last year, researchers from Kusuma School of Biological Sciences in IIT Delhi and Acharya Narendra Dev College under Delhi University had published a paper, where they had found that the spike glycoprotein (S) of SARS-CoV-2 had four insertions which are not found in any other Coronavirus, and the insertions are similar to those found in HIV virus. The study had raised that possibility that SARS-CoV-2 may have been bio-engineered using the existing Coronavirus and HIV virus.
The research paper, Prashant Pradhan, Ashutosh Kumar Pandey, Akhilesh Mishra, Parul Gupta, Praveen Kumar Tripathi, Manoj Balakrishnan Menon, James Gomes, Perumal Vivekanandan and Bishwajit Kundu, had studied the all the available coronavirus sequences which are available at NCBI viral genome database.
The spike (S) glycoproteins enable the Coronavirus to enter the cells of human bodies. Studies have shown that the glycoprotein has a specific shape that helps them to attach to host cells, and this ability is unique to the SARS-CoV-2, not found in other types of Coronaviruses like SARS-CoV. More specifically, the spike glycoprotein (S) of Coronavirus is cleaved into two subunits, S1 and S2. The S1 helps in binding with the receptor on the target cell, and the S2 subunit facilitates fusion with the cell membrane.
As this splitting of the glycoprotein in SARS-CoV-2 is unique to it, the Indian researchers wanted to study how this evolution happened. To do this study, they compared the spike glycoprotein sequences of the SARS-CoV-2 with SARS-CoV, and analysed the difference in them. On careful examination of the sequence alignment, they found that the SARS-CoV-2 spike glycoprotein contained 4 insertions, or 4 segments that are not found in the earlier less infectious forms of Coronavirus.
The four insertions found in the study are, GTNGTKR, HKNNKS, GDSSSG and QTNSPRRA."
"After finding this, they then studiedall available full-length sequences of the virus found in human bodies, and they found that the insertions were present in all of them. But most importantly, the found thatthese segments were not there in the spike glycoprotein sequence of the same virus found in bats.
When they further analysed these 4 segments to know its possible origin, they found thatall four them match with segments in Human immunodeficiency Virus-1(HIV-1) proteins. The first 3 segments match with segments of amino acid residues in HIV-1 gp120, while the fourth segment matches with HIV-1 Gag. Among the four, the first two are 100% matches, while the rest two have some gaps. These proteins are critical for the viruses to identify and latch on to their host cells and for assembly of new viruses.
According to the researchers,such matches of proteins in both SARS-CoV-2 and HIV-1 viruses can't be random. They also say that asthe segments were not there in the same virus found in bats or all other forms of Coronavirus, it is very startling, as it is quiteunlikely for a virus to have acquired such unique changes naturally in a short duration of time. It may be noted thatit is claimed that the virus jumped to humans from bats, either directly or through an intermediary animal."
#10663029 at 2020-09-16 02:18:09 (UTC+1)
Q Research General #13646: The Fuck China - Good Things For Everybody Edition
>>10662795 (pb) More tampering of virus papers
This was released in January 2020. I remember chasing this down then and there were at least 4 other papers posted in "Pre-review" sites. They were blasted at the time for being posted before they had been vetted, even though the site was were the vetting was supposed to occur.
https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1
Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
Prashant Pradhan, Ashutosh Kumar Pandey, Akhilesh Mishra, Parul Gupta, Praveen Kumar Tripathi, Manoj Balakrishnan Menon, James Gomes, Perumal Vivekanandan, Bishwajit Kundu
Abstract
We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019-nCoV). The evolution of 2019-nCoV remains elusive. We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all the 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-1 Gag. Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site. The finding of 4 unique inserts in the 2019-nCoV, all of which have identity /similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature. This work provides yet unknown insights on 2019-nCoV and sheds light on the evolution and pathogenicity of this virus with important implications for diagnosis of this virus.
#9100264 at 2020-05-09 22:32:08 (UTC+1)
Q Research General #11648: Xi & Biden Toasting Their Own Destruction Edition
Insert removed? Was it the HIV component?? Thoughts?
Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
Prashant Pradhan, Ashutosh Kumar Pandey, Akhilesh Mishra, Parul Gupta, Praveen Kumar Tripathi, Manoj Balakrishnan Menon, James Gomes, Perumal Vivekanandan, Bishwajit Kundu
doi: https://doi.org/10.1101/2020.01.30.927871
This article is a preprint and has not been certified by peer review [what does this mean?].
AbstractFull TextInfo/HistoryMetrics Preview PDF
Abstract
We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019-nCoV). The evolution of 2019-nCoV remains elusive. We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all the 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-1 Gag. Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site. The finding of 4 unique inserts in the 2019-nCoV, all of which have identity /similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature. This work provides yet unknown insights on 2019-nCoV and sheds light on the evolution and pathogenicity of this virus with important implications for diagnosis of this virus.
https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1
8chan/8kun QRB Posts (2)
#59623 at 2021-06-03 23:29:18 (UTC+1)
QRB General #263: WHO's The Nazi Now? Edition
>>59619
Research withdrawn: Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
Prashant Pradhan, Ashutosh Kumar Pandey, Akhilesh Mishra, Parul Gupta, Praveen Kumar Tripathi, Manoj Balakrishnan Menon, James Gomes, Perumal Vivekanandan, Bishwajit Kundu
doi: https://doi.org/10.1101/2020.01.30.927871
Abstract
_This paper has been withdrawn by its authors. They intend to revise it in response to comments received from the research community on their technical approach and their interpretation of the results._ If you have any questions, please contact the corresponding author.
https://www.biorxiv.org/content/10.1101/2020.01.30.927871v2
#59619 at 2021-06-03 23:09:54 (UTC+1)
QRB General #263: WHO's The Nazi Now? Edition
January 30, 2020: Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1
Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
Abstract:
We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019-nCoV). The evolution of 2019-nCoV remains elusive. _We found 4 insertions in the spike glycoprotein(S) which are unique to the 2019-nCoV and are not present in other coronaviruses._ Importantly, _amino acid residues in all the 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-1 Gag._ Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site._The finding of 4 unique inserts in the 2019-nCoV, all of which have identity /similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature. This work provides yet unknown insights on 2019-nCoV and sheds light on the evolution and pathogenicity of this virus with important implications for diagnosis of this virus.
Conclusions
Our analysis of the spike glycoprotein of 2019-nCoV revealed several interesting findings: _First, we identified 4 unique inserts in the 2019-nCoV spike glycoprotein that are not present in any other coronavirus reported till date. To our surprise, all the 4 inserts in the 2019-nCoV mapped to short segments of amino acids in the HIV-1 gp120 and Gag among all annotated virus proteins in the NCBI database. This uncanny similarity of novel inserts in the 2019- nCoV spike protein to HIV-1 gp120 and Gag is unlikely to be fortuitous. Further, 3D modelling suggests that at least 3 of the unique inserts which are non-contiguous in the primary protein sequence of the 2019-nCoV spike glycoprotein converge to constitute the key components of the receptor binding site. Of note, all the 4 inserts have pI values of around 10 that may facilitate virus-host interactions. Taken together, our findings suggest unconventional evolution of 2019-nCoV that warrants further investigation. Our work highlights novel evolutionary aspects of the 2019-nCoV and has implications on the pathogenesis and diagnosis of this virus._
January 2020
DOI:10.1101/2020.01.30.927871
Authors:
Prashant Pradhan/Indian Institute of Technology Delhi
Ashutosh Kumar Pandey/Indian Institute of Technology Delhi
Akhilesh Mishra
Parul Gupta/Stanford University
Praveen Kumar Tripathi/Indian Institute of Technology Delhi
Manoj Balakrishna Menon
James Gomes
Vivekanandan Perumal/Indian Institute of Technology Delhi
Bishwajit Kundu/ Indian Institute of Technology Delhi
cont...
https://www.researchgate.net/publication/338957445_Uncanny_similarity_of_unique_inserts_in_the_2019-nCoV_spike_protein_to_HIV-1_gp120_and_Gag